Glucosamine (GS) is a supplement used by many active individuals who want to maintain healthy joints and prevent osteoarthritis. It is also said to relieve pain as well as increase flexibility or range of motion in the joints. Glucosamine is most effective when it is combined with MSM and Chondroitin Sulfate (CS). Research suggests that oral intakes of Glucosamine and chondroitin, either alone or in combination, reduces joint pain and improves mobility in persons with osteoarthritis. A multivitamin and essential fats such as fish oils, omega oils and flax oil supplements are also suggested for best results.